Clinical article

Preservation of Residual Radicular Pulp: A Biologically Guided Vital Pulp Therapy Protocol for Immature Teeth with Fractured Dens Evaginatus and Apical Periodontitis

Mitsuhiro Tsukiboshi, DDS, PhD¹*

https://doi.org/10.71347/fe20bk39


¹ Private practice, Aichi, Japan. E-mail: info@tsukiboshi-dc.com

*Corresponding author:

Mitsuhiro Tsukiboshi E-mail: E-mail: info@tsukiboshi-dc.com


Key words: Dens evaginatus, Vital pulp therapy, Apical periodontitis, Immature permanent teeth, Residual

radicular pulp, Pulp preservation

Acknowledgements: The author declares no conflicts of interest and would like to thank Dr. Domenico Ricucci and Dr. Franklin Tay for their valuable contributions to the improvement of the manuscript.

Cite this article

Abstract


Background

Immature permanent teeth with fractured dens evaginatus frequently develop apical periodontitis before completion of root formation. These teeth are commonly managed as completely necrotic, although viable radicular pulp may persist despite periapical disease. Recognition of residual radicular pulp may permit a more conservative biologically based treatment strategy.

Objective

To describe a biologically guided vital pulp therapy protocol based on preservation of residual radicular pulp and to evaluate its clinical application in a consecutive series of immature premolars with fractured dens evaginatus and apical periodontitis.

references

American Association of Endodontists. AAE Position Statement on Vital Pulp Therapy. Chicago, IL: American Association of Endodontists; 2021. https://www.aae.org/wp-content/uploads/2021/05/VitalPulpTherapy_PositionStatement_v2.pdf

Ayer A, Vikram M, Suwal P (2015). Dens Evaginatus: A Problem-Based Approach. Case Reports in Dentistry, 2015, 393209. https://doi.org/10.1155/2015/393209

Banchs F, Trope M (2004). Revascularization of immature permanent teeth with apical periodontitis: new treatment protocol? Journal of Endodontics, 30(4), 196–200. https://doi.org/10.1097/00004770-200404000-00003

Boudi R, Sakout M, Ramdi H (2025). The Extra Cusp Mystery: Exploring Dens Evaginatus. Cureus, 17(10), e94526. https://doi.org/10.7759/cureus.94526

Boufdil H, Mtalsi M, El Arabi S, Bousfiha B (2020). Apexification with Calcium Hydroxide vs. Revascularization. Case Reports in Dentistry, 2020, 9861609. https://doi.org/10.1155/2020/9861609

Chen JW, Huang GT, Bakland LK (2020). Dens evaginatus: Current treatment options. Journal of the American Dental Association, 151(5), 358–367. https://doi.org/10.1016/j.adaj.2020.01.015

Chueh LH, Huang GT (2006). Immature teeth with periradicular periodontitis or abscess undergoing apexogenesis: a paradigm shift. Journal of Endodontics, 32(12), 1205–1213. 

Colloc TNE, Tomson PL (2025). Vital pulp therapies in permanent teeth: what, when, where, who, why and how? British Dental Journal, 238(7), 458–468. https://doi.org/10.1038/s41415-025-8560-3

Duncan HF (2022). Present status and future directions-Vital pulp treatment and pulp preservation strategies. International Endodontic Journal, 55 Suppl 3(Suppl 3), 497–511. https://doi.org/10.1111/iej.13688

European Society of Endodontology (ESE) developed by: Duncan HF, Galler KM, Tomson PL, Simon S, El-Karim I, Kundzina R, Krastl G, Dammaschke T, Fransson H, Markvart M, Zehnder M, Bjørndal L (2019). European Society of Endodontology position statement: Management of deep caries and the exposed pulp. International Endodontic Journal, 52(7), 923–934. https://doi.org/10.1111/iej.13080

Hargreaves KM, Diogenes A, Teixeira FB (2013). Treatment options: biological basis of regenerative endodontic procedures. Journal of Endodontics, 39(3 Suppl), S30–S43. https://doi.org/10.1016/j.joen.2012.11.025

Lerdrungroj K, Banomyong D, Nakornchai S, Ngoenwiwatkul Y, Porkaew P (2022). Outcomes and Predisposing Factors of Two Prophylactic Treatments in Dens Evaginatus Premolars: A Retrospective Study. Journal of Endodontics, 48(7), 864–871. https://doi.org/10.1016/j.joen.2022.04.004

Lerdrungroj K, Banomyong D, Songtrakul K, Porkaew P, Nakornchai S (2023). Current Management of Dens Evaginatus Teeth Based on Pulpal Diagnosis. Journal of Endodontics, 49(10), 1230–1237. https://doi.org/10.1016/j.joen.2023.07.017

Levitan ME, Himel VT (2006). Dens evaginatus: literature review, pathophysiology, and comprehensive treatment regimen. Journal of Endodontics, 32(1), 1–9. https://doi.org/10.1016/j.joen.2005.10.009

Lin CS, Llacer-Martinez M, Sheth CC, Jovani-Sancho M, Biedma BM (2018). Prevalence of Premolars with Dens Evaginatus in a Taiwanese and Spanish Population and Related Complications of the Fracture of its Tubercle. European Endodontic Journal, 3(2), 118–122. https://doi.org/10.14744/eej.2018.08208

Moorrees CFA, Fanning EA, Hunt EE Jr (1963). Age variation of formation stages for 10 permanent teeth. Journal of Dental Research, 42, 1490-1502.

Naini FB, Levisianos I, Foo L, Gill DS (2018). Pre-eruptive diagnosis and management of occlusal dens evaginatus in premolar teeth. Dental Update, 45(9), 882–888. https://doi.org/10.12968/denu.2018.45.9.882

Oehlers FA, Lee KW, Lee EC (1967). Dens evaginatus (evaginated odontome). Its structure and responses to external stimuli. Dental Practitioner and Dental Record 17(7), 239-244. 

Ricucci D, Loghin S, Siqueira JF Jr (2014). Correlation between clinical and histologic pulp diagnoses. Journal of Endodontics, 40(12), 1932–1939. https://doi.org/10.1016/j.joen.2014.08.010

Ricucci D, Siqueira JF Jr, Li Y, Tay FR (2019). Vital pulp therapy: histopathology and histobacteriology-based guidelines to treat teeth with deep caries and pulp exposure. Journal of Dentistry, 86, 41–52. https://doi.org/10.1016/j.jdent.2019.05.022

Sim TP (1996). Management of dens evaginatus: evaluation of two prophylactic treatment methods. Endodontics & Dental Traumatology, 12(3), 137–140. https://doi.org/10.1111/j.1600-9657.1996.tb00112.x

Sumiya Y (1959). Statistic study on dental anomalies in the Japanese. The Journal of the Anthropological Society of Nippon 67, 215-233.

Tsukiboshi M, Ricucci D, Siqueira JF Jr (2017). Mandibular Premolars with Immature Roots and Apical Periodontitis Lesions Treated with Pulpotomy: Report of 3 Cases. Journal of Endodontics, 43(9S), S65–S74. https://doi.org/10.1016/j.joen.2017.06.013

Uyeno DS, Lugo A (1996). Dens evaginatus: a review. ASDC Journal of Dentistry for Children, 63(5), 328–332.

van der Vyver PJ, Vorster M, Buchanan GD (2023). Apexification of dens evaginatus in a mandibular premolar: A case report. Clinical Case Reports, 11(5), e07316. https://doi.org/10.1002/ccr3.7316

Van Pham K, Tran TA (2021). Effectiveness of MTA apical plug in dens evaginatus with open apices. BMC Oral Health, 21(1), 566. https://doi.org/10.1186/s12903-021-01920-6

Wang FM, Charunmethee P, Augsburger RA, Gutmann JL (2020). Vital pulp therapy of a dens evaginatus-affected tooth with an immature apex and inflamed pulpal and periapical tissue: a case report. General Dentistry, 68(3), 62–65.